Abbott poc istat creatinine calibration12/24/2023 ![]() ![]() ![]() Methods: Patient serum samples with known creatinine levels were pooled to create three standards – normal range (NR), high (H), and very high (VH) creatinine. We sought to characterize the extent of this interference and to compare results with the epoc, a POCT device similar to the i-STAT. This interference can lead to differences between creatinine and glucose results reported from the i-STAT and samples analyzed with other methods. Might be worth keeping this in mind.īackground: Measurements of creatinine and glucose on the i-STAT point-of-care testing (POCT) device are known to be elevated in the presence of hydroxyurea. And it looks like the hyroxyurea has the same effect on the iSTAT glucose reading and parcetamol (not at therapeutic levels but potentially in an overdose) might have the same effect of falsely elevating the iSTAT creatinine. The manufacturers advice when an patient is on hydroxyurea is ‘use another method’ to test the creatinine. The problem in the end turned out to be the hyroxyurea that patient was on – which falsely elevates iSTAT POC creatinine levels. Repeated tests done on both the iStat and in the main lab using the same samples kept returning a similar large disparity in creatinine levels. The next day his creatinine done in the main lab was 70 micromol/L. We had a recent experience of an elderly patient who had a iSTAT POC creatinine of > 200 micromol/L and who we managed as AKI overnight. Many of us rely on iSTAT POC bloods some, or all of the time. Spurious iSTAT POC creatinine (and glucose) results with hydroxyurea Hod, Alexander Kratz, 57: Hydroxyurea Interference in Point-of-Care Creatinine and Glucose Measurements, American Journal of Clinical Pathology, Volume 143, Issue suppl_1,, Page A030, ![]()
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